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KMID : 0613820090190081145
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Journal of Life Science
2009 Volume.19 No. 8 p.1145 ~ p.1151
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Effects of Sasa coreana, Nakai on the Lipid Compositions of Serum in High Cholesterol Diet Rats
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Park Jong-Ok
Jang Hye-Won
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Abstract
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This study was performed to investigate the effects of Sineui-Dae (Sasa coreana Nakai, a kind of bamboo) extracts on the improvement of serum lipid composition by using rats fed a hypercholesterol diet for 4 weeks. The experiment animals were administered with the following diets; high cholesterol diet group (HC diet) as a control and three supplemented groups with high cholesterol diets (HCW, HCM or HCH diet). Three kinds of extracts were prepared by orderly extraction with hexane, methanol, and water. We measured free cholesterol, cholesteryl ester, total cholesterol, LDL- and HDL-cholesterol, triglyceride and phospholipid in the serum of rats in three experimental and control groups. There were no significant differences in body weights and feed intakes between the HC control group and the extract supplemented groups. The levels of total cholesterol and LDL-cholesterol in the serum of extract supplemented groups were lower than that of the group fed with HC diet only. Serum HDL-cholesterol level, which is known as an antiatherosclerosis factor, was higher in all groups supplemented with bamboo extract by 17.2-21.9% compared to the HC control group. All groups supplemented with bamboo extracts showed the lowering effect of atherogenic index compared to the HC control group (HC group: 2.96±0.08, HCM group: 1.48±0.02, HCW group: 1.69±0.04, HCH group: 1.84±0.01). Furthermore, serum triglyceride and phospholipid decreased significantly in the HCM diet compared to the HC control diet. These results suggest that Sineui-Dae bamboo extract, especially methanol extract, has improving effects on hyperlipidemia of rats fed a high cholesterol diet.
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KEYWORD
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Sasa coreana Nakai, hypercholesterol diet, atherogenic index, hyperlipidemia
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